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Synthesis
DOI: 10.1055/a-2741-9499
DOI: 10.1055/a-2741-9499
Short Review
Recent Advances in Catalytic Hydroamidation Reactions of Unsaturated Substrates with Dioxazolones
Authors
Financial support was received from the Basic Research Program of Jiangsu (BK20251604), the Jiangsu Funding Program for Excellent Postdoctoral Talent (2025ZB280), the Wuxi Science and Technology Development Fund Project (K20241039), the foundation of Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, Jiangnan University (1042050205255750/008), and the Fundamental Research Funds for the Central Universities (JUSRP202501042).
Supported by: The foundation of Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, Jiangnan University 1042050205255750/008
Supported by: The Fundamental Research Funds for the Central Universities JUSRP202501042
Supported by: The Wuxi Science and Technology Development Fund Project K20241039
Supported by: The Basic Research Program of Jiangsu BK20251604
Abstract
Transition metal–catalyzed hydroamidation of alkenes and alkynes represents an efficient method for synthesizing structurally diverse amides, which are ubiquitously found in natural products, bioactive molecules, and pharmaceutical agents. In this context, dioxazolones have attracted extensive research attention as readily accessible and reactive amidating reagents. Herein, we summarize the advancements in hydroamidation reactions of alkenes and alkynes with dioxazolones, categorizing them according to the reaction mechanisms and classifying each section by the type of metal catalysts employed. We provide a comprehensive discussion of the scope and limitations, proposed mechanisms, and the opportunities for future development.
Publication History
Received: 15 October 2025
Accepted after revision: 07 November 2025
Article published online:
27 November 2025
© 2025. Thieme. All rights reserved.
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