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DOI: 10.1055/a-2784-2470
An Update on the Total Synthesis of (S)-Quisqualic Acid and Its Derivatives
Authors
This work was supported by the Slovak Research and Development Agency under the Contract no. APVV-21-0108.
Abstract
(S)-Quisqualic acid and its structural analogues show potent activity across various fields of medicine. The growing interest in this amino acid family creates a pressing need for detailed synthetic procedures. Here, we present a comprehensive synthesis of N-Boc-(S)-quisqualic acid from l-serine with an overall yield of 58% over six steps. Further transformation into the C-protected (S)-quisqualic acid and the unprotected (S)-quisqualic acid HCl salt is also feasible with good yields. The complete characterization (NMR, HRMS, IR) of the intermediates and target molecules allows the reliable utilization of this synthetic work.
Publication History
Received: 17 November 2025
Accepted after revision: 08 January 2026
Accepted Manuscript online:
08 January 2026
Article published online:
20 January 2026
© 2026. Thieme. All rights reserved.
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