In vitro Anti-Influenza Viral Activities of Constituents from Caesalpinia sappan

Abstract

Six constituents with neuraminidase (NA) inhibitory activity, namely brazilein, brazilin, protosappanin A, 3-deoxysappanchalcone, sappanchalcone and rhamnetin, were isolated from the hearthwood of Caesalpinia sappan (Leguminosae). Their in vitro anti-influenza virus activities were evaluated with the cytopathic effect (CPE) reduction method. The results showed that 3-deoxysappanchalcone and sappanchalcone exhibited the highest activity against influenza virus (H3N2) with IC₅₀ values of 1.06 and 2.06 μg/mL, respectively, in comparison to the positive control oseltamivir acid and ribavirin with IC₅₀ values of 0.065 and 9.17 μg/mL, respectively.

Abbreviations

CPE:cytopathic effect

NA:neuraminidase

Caesalpinia sappan - Leguminosae - influenza virus - neuraminidase - sappanchalcone

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