Planta Med 2009; 75(11): 1258-1261
DOI: 10.1055/s-0029-1185545
Natural Product Chemistry
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Antimicrobial Dihydroisocoumarins from Crassocephalum biafrae

Turibio K. Tabopda1 , Gislain W. Fotso1 , Joseph Ngoupayo1 , Anne-Claire Mitaine-Offer2 , Bonaventure T. Ngadjui1 , Marie-Aleth Lacaille-Dubois2
  • 1Département de Chimie Organique, Université de Yaoundé I, Yaoundé, Cameroon
  • 2Université de Bourgogne, Faculté de Pharmacie, Laboratoire de Pharmacognosie, Dijon cedex, France
Further Information

Publication History

received November 24, 2008 revised February 18, 2009

accepted February 28, 2009

Publication Date:
06 April 2009 (online)

Abstract

Bioassay-guided fractionation of the CHCl3-soluble extract of the stem bark of Crassocephalum biafrae (Asteraceae) resulted in the isolation of three new dihydroisocoumarins, named biafraecoumarins A (1), B (2), and C (3); two known triterpenes (4 and 5); and a known ceramide (6). The structures of the new compounds were established as 7-but-15-enyl-6,8-dihydroxy-3(R)-penta-9,11-dienylisochroman-1-one (1), 7-butyl-6,8-dihydroxy-3(R)-penta-9,11-dienylisochroman-1-one (2), and 7-butyl-6,8-dihydroxy-3(R)-pent-10-enylisochroman-1-one (3) using spectroscopic data. Compounds 13 exhibit low to significant antimicrobial activities against Escherichia coli, Bacillus subtilis, Staphylococcus aureus, Pseudomonas picketti, Trichphyton longifusus, Aspergillus flavus, Microsporum canis, Fusarium solani, Candida albicans, and Candida glabrata.

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Dr. Turibio Kuiate Tabopda

Département de Chimie Organique
Université de Yaoundé I

BP 812 Yaoundé

Cameroun

Phone: + 2 37 77 97 66 33

Fax: + 2 37 22 22 18 73

Email: ttabopda@yahoo.fr

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