Three New Acylated Glycosides from the Stems of Casearia velutina and their Protective Effect Against H₂O₂-Induced Impairment in PC12 Cells

Abstract

Chemical investigation of the stems of Casearia velutina led to the isolation and structural elucidation of three new acylated glycosides, casearicosides A–C (1–3), together with 13 known compounds. The structures of the new compounds were established by spectroscopic and chemical methods. These isolates were evaluated for protective effects against H₂O₂-induced impairment in PC12 cells and inhibitory activity against snake venom phosphodiesterase I. A brief chemotaxonomy of the genus Casearia is also discussed.

Casearia velutina Blume - Salicaceae - casearicosides A–C - Flacourtiaceae - chemotaxonomy

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