Planta Med 2010; 76(2): 140-145
DOI: 10.1055/s-0029-1186002
Natural Product Chemistry
Original Papers
© Georg Thieme Verlag KG Stuttgart · New York

Ent-Kaurane Diterpenoids from Rabdosia rubescens and Their Cytotoxic Effects on Human Cancer Cell Lines

Naisheng Bai1 , Kan He2 , Zhu Zhou3 , Mei-Ling Tsai4 , Li Zhang1 , Zheng Quan2 , Xi Shao1 , Min-Hsiung Pan4 , Chi-Tang Ho1
  • 1Department of Food Science, Rutgers University, New Brunswick, New Jersey, USA
  • 2Naturex Inc., South Hackensack, New Jersey, USA
  • 3College of Pharmacy, Fudan University, Shanghai, People's Republic of China
  • 4Department of Seafood Science, National Kaohsiung Marine University, Kaohsiung, Taiwan
Further Information

Publication History

received March 5, 2009 revised May 18, 2009

accepted June 29, 2009

Publication Date:
03 August 2009 (online)

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Abstract

Two new ent-kaurane diterpenoids, 16,17-exo-epoxide-oridonin (1) and 11,15-O,O-diacetyl-rabdoternins D (2), together with thirteen known ones, were isolated from the aerial parts of Rabdosia rubescens. Their structures were established on the basis of high-field 1D and 2D NMR methods supported by HRMS. All diterpenoids were tested for cytotoxicity against human Hep G2, COLO 205, MCF-7, and HL-60 cancer cells. The compounds oridonin (3), 14-O-acetyl-oridonin (4), 1,14-O,O-diacetyl-oridonin (5), rosthorin (6), effusanin E (7), and ponicidin (8), as well as six α-methylene γ-ketone bearing diterpenoids, were modestly active in these assays.

References

Chi-Tang Ho

Department of Food Science
Rutgers University

65 Dudley Road

New Brunswick, NJ 08901

USA

Phone: + 1 73 29 32 96 11 ext. 235

Fax: + 1 73 29 32 67 76

Email: ho@aesop.rutgers.edu