Heteroarylsulfonates in Iron-Catalyzed Coupling with Alkyl
Grignard Reagents

T. M. Gøgsig; A. T. Lindhardt; T. Skrydstrup

doi:10.1055/s-0029-1218428

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Synfacts 2010(1): 0088-0088
DOI: 10.1055/s-0029-1218428

Metal-Mediated Synthesis

Heteroarylsulfonates in Iron-Catalyzed Coupling with Alkyl Grignard Reagents

Contributor(s): Paul Knochel, Andrei Gavryushin
T. M. Gøgsig, A. T. Lindhardt, T. Skrydstrup*
Aarhus University, Denmark

Further Information

Publication History

Publication Date:
21 December 2009 (online)

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Significance

Activated heteroaromatic tosylates (derived from pyridines, pyrimidines, pyrazines, and quinoxalines) and phosphates undergo a smooth iron-catalyzed cross-coupling with primary and secondary alkylmagnesium halides. Functional groups such as nitriles, amides, and esters are well tolerated.