Synfacts 2010(1): 0075-0075  
DOI: 10.1055/s-0029-1218475
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Three-Component Diastereoselective Synthesis of Pyrrolidinones

Contributor(s): Mark Lautens, David A. Candito
S. M.-C. Pelletier, P. C. Ray, D. J. Dixon*
University of Oxford and Schering-Plough Research Institute, Motherwell, UK
Further Information

Publication History

Publication Date:
21 December 2009 (online)

Significance

Building upon previous work (A. L. Tillman, J. Ye, D. J. Dixon Org. Lett. 2008, 10, 4267) the authors report a three-component nitro-Mannich/lactamization cascade for the diastereoselective synthesis of pyrrolidinones. The protocol is operationally simple and provides access to a large number of pyrrolidinones in moderate to good yields and generally excellent diastereoselectivity.