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Synthesis 2010(14): 2407-2412  
DOI: 10.1055/s-0029-1218775
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

A Stereoselective Aldol Approach for the Total Synthesis of Herbarumin I and Stagonolide A

P. Srihari*, G. Maheswara Rao, R. Srinivasa Rao, J. S. Yadav
Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad 500607, India
Fax: +91(40)27160512; Fax: +91(40)27160387; e-Mail: srihari@iict.res.in;
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Publikationsverlauf

Received 8 March 2010
Publikationsdatum:
05. Mai 2010 (online)

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Abstract

A stereoselective total synthesis of phytotoxic compounds herbarumin I and stagonolide A has been achieved utilizing Crimmin’s protocol for non-Evans anti-aldol approach and a ring-closing olefin metathesis reaction as the key steps.

Key words

macrolide - phytotoxic - Evans aldol - olefin metathesis

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