Download PDF
Planta Med 2000; 66(1): 91-93
DOI: 10.1055/s-0029-1243121
Letter

© Georg Thieme Verlag Stuttgart · New York

Interaction of Flavones from the Roots of Scutellaria baicalensis with the Benzodiazepine Site

Kwok Min Hui1 , Xi Hong Wang1 , 2 , Hong Xue1 ,*
  • 1Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
  • 2National Laboratories of Natural and Biomimetic Drugs, Beijing Medical University, Beijing, P. R. China
Further Information

Publication History

Received: April 21, 1999

Accepted: June 27, 1999

Publication Date:
24 November 2009 (online)

    Permissions and Reprints

Abstract

A radioreceptor binding assay was used to guide the isolation of four chemical constituents in the organic solvent extracts of Scutellaria baicalensis Georgi capable of binding to the benzodiazepine site (BZD-S) of the GABAA receptor: wogonin (Ki = 2.03 ± 0.24µM), baicalin (Ki = 77.10 ± 4.79µM), baicalein (Ki = 5.69 ± 0.95µM), and scutellarein (Ki = 12.00 ± 1.27µM). All four compounds contain the flavonoid phenylbenzopyrone nucleus. Based on BZD-S binding, the order of affinity among these four compounds was wogonin > baicalein > scutellarein > baicalin.

References

  • 1 Huang K C. In: The Pharmacology of Chinese Herbs. CRC press 1993: pp. 290-291
    Google Scholar
  • 2 Ai J, Dekermendijian K, Wang X, Nielsen M, Witt M R. Drug Develop Res 1997 41: 99-106
  • 3 Liao J F, Wang H H, Chen M C, Chen C C, Chen C F. Planta Med 1998 64: 571-572
  • 4 Tomimori T, Miyaichi Y, Imoto Y, Kizu H. Shoyakugaku Zasshi 1984 38: 249-252
  • 5 Miyaichi Y, Imoto Y, Saida H, Tomimori T. Shoyakugaku Zasshi 1998 42: 216-219
  • 6 Zhang Y Y, Guo Y Z, Onda M, Hashimoto K, Ikeya Y, Okada M, Maruno M. Phytochem 1994 35: 511-514
  • 7 Tomimori T, Miyaichi Y, Kizu H. Yakugaku Zasshi 1982 102: 388-391
  • 8 Miyaichi Y, Imoto Y, Tomimori T, Namba T. Chem Pharm Bull 1988 36: 2371-2376
  • 9 Vogel H G, Vogel W H. In Drug Discovery and Evaluation: Pharmacology Assay . New York; Springer 1997: pp 218-219
    Google Scholar
  • 10 Squires R F, Braestrup C. Nature 1977 266: 732-734
  • 11 Cheng Y, Prusff W H. Biochem Pharm 1973 22: 3099-3108

Dr. Hong Xue

Department of Biochemistry

Hong Kong University of Science and Technology

Clear Water Bay

Kowloon

Hong Kong

Email: hxue@ust.hk

Phone: +852-2358-8707

Fax: +852-2358-1552

      >