Antitussive Indole Alkaloids from Kopsia hainanensis

Min-Jia Tan; Chun Yin; Chun-Ping Tang; Chang-Qiang Ke; Ge Lin; Yang Ye

doi:10.1055/s-0030-1250631

Planta Medica, Table of Contents

Planta Med 2011; 77(9): 939-944
DOI: 10.1055/s-0030-1250631

Natural Product Chemistry

Original Papers
© Georg Thieme Verlag KG Stuttgart · New York

Antitussive Indole Alkaloids from Kopsia hainanensis

Min-Jia Tan¹ , Chun Yin² , Chun-Ping Tang¹ , Chang-Qiang Ke¹ , Ge Lin² , Yang Ye¹

¹State Key Laboratory of Drug Research & Natural Products Chemistry Department, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P. R. China
²School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong SAR, P. R. China

Abstract

Three new indole alkaloids, named kopsihainins A–C (1–3), and two known compounds, kopsinine (4) and methyl demethoxycarbonylchanofruticosinate (5), were isolated from the stems of Kopsia hainanensis. Their structures were determined using extensive spectroscopic methods. The two main constituents 4 and 5 exhibited significant antitussive activity in a citric acid induced guinea pig cough model. The antitussive effect of 4 was demonstrated to interact with the δ-opioid receptor. This is the first report of antitussive effects of aspidofractinine type and chanofruticosinate type alkaloids.

Key words

Kopsia hainanensis - Apocynaceae - danuphyllin type - aspidofractinine type - chanofruticosinate type - antitussive activity

Full Text

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Prof. Yang Ye

State Key Laboratory of Drug Research & Natural Products Chemistry Department
Shanghai Institute of Materia Medica
Chinese Academy of Sciences

555 Zu-Chong-Zhi Road, Zhangjiang Hightech Park

Shanghai 201203

P. R. China

Phone: +86 21 50 80 67 26

Fax: +86 21 50 80 67 26

Email: yye@mail.shcnc.ac.cn

Prof. Ge Lin

School of Biomedical Sciences
The Chinese University of Hong Kong

Shatin, N. T.

Hong Kong SAR

P. R. China

Phone: +85 2 26 09 68 24

Fax: +85 2 26 03 51 39

Email: linge@cuhk.edu.hk

Supplementary Material

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