Synthesis 2011(3): 459-462  
DOI: 10.1055/s-0030-1258393
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

One-Pot Synthesis of 2,4,5-Triaryl-1H-imidazoles from Arylaldehydes, Benzyl Alcohols, or Benzyl Halides with Hexamethyldisilazane in Molten Tetrabutylammonium Bromide

Javad Salehi*a, Mohammad M. Khodaeib, Ahmad R. Khosropourb
a Department of Pharmacology, Hamadan University of Medical Science, Hamadan, Iran
b Department of Chemistry, Razi University of Kermanshah, Kermanshah, Iran
Fax: +98(811)8276299; e-Mail: javadsalehi_58@yahoo.com;
Further Information

Publication History

Received 15 November 2010
Publication Date:
11 January 2011 (online)

Abstract

A simple and efficient method for the synthesis of 2,4,5-triaryl-1H-imidazole derivatives in good to excellent yields by reaction between hexamethyldisilazane and arylaldehydes, benzyl alcohols, benzyl halides in molten tetrabutylammonium bromide as an inexpensive and non toxic solvent has been developed. The remarkable advantages of this method are the simple workup procedure, high yields of products, the use of an ionic liquid as a green solvent, and the availability of reagents.

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