A Practical Synthesis of 2-Aroylindoles from N-(2-Formylphenyl)trifluoro­acetamides in PEG-400

Abstract

A one-pot and environmentally benign approach to the synthesis of highly functionalized 3-unsubstituted 2-aroylindoles is described. Moderate to good yields were obtained through the reaction of easily accessible N-(2-formylphenyl)trifluoroacetamides and α-bromoacetophenones in the presence of K₂CO₃. PEG-400 was found to be an efficient and reusable solvent in the process.

2-aroylindoles - PEG-400 - N-(2-formylphenyl)trifluoro­acetamides - heterocycles - cyclization

References

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