Download PDF
Synfacts 2010(12): 1435-1435  
DOI: 10.1055/s-0030-1258928
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Modification of a Vitamin D Analogue Using a Supported Selenium Reagent

Contributor(s): Yasuhiro Uozumi, Yoichi M. A. Yamada, Maki Minakawa
W.-M. Xu*, J. He, M.-Q. Yu, G.-X. Shen
Hangzhou Normal University, P. R. of China
Further Information

Publication History

Publication Date:
22 November 2010 (online)

    Permissions and Reprints

Significance

A site-selective modification of a ­vitamin D analogue (deltanoid) using a poly­styrene-supported selenium reagent was described. The modified vitamin D2 attached to the selenium resin was readily converted into 9, the key intermediate of calcipotriol, via organoselenium-assisted [2,3]-sigmatropic rearrangement.