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Synfacts 2010(12): 1418-1418
DOI: 10.1055/s-0030-1258931
DOI: 10.1055/s-0030-1258931
Organo- and Biocatalysis
© Georg Thieme Verlag
Stuttgart ˙ New York
Organocatalytic Corey-Chaykovsky Reaction of Ketones
S. A. Kavanagh, A. Piccinini, S. J. Connon*
University of Dublin, Ireland
Further Information
Publication History
Publication Date:
22 November 2010 (online)
Significance
The authors report the metal-free, catalytic Corey-Chaykovsky reaction of ketones. The catalyst system, sulfide 1 in combination with P2-phosphazene base, proton sponge, and MeOTf as methylene source, delivered various aromatic and aliphatic epoxide products in high yields.