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Synfacts 2010(12): 1362-1362
DOI: 10.1055/s-0030-1258934
DOI: 10.1055/s-0030-1258934
Synthesis of Materials and Unnatural Products
© Georg Thieme Verlag
Stuttgart ˙ New York
Scale Up, Spice Up
J.-D. Chen, H.-Y. Lu, C.-F. Chen*
Institute of Chemistry, Chinese Academy of Sciences and Graduate School of Chinese Academy of Sciences, Beijing, P. R. of China
Further Information
Publication History
Publication Date:
22 November 2010 (online)
Significance
The authors reported an efficient route to prepare benzo[5]helicene (4) with the key step being the Diels-Alder reaction between benzyne and diene 2. Benzo[7]helicene can also be synthesized in a similar fashion in 21% overall yield. This method can be performed on gram scale from commercially available starting materials.