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Planta Med 2012; 78(3): 290-296
DOI: 10.1055/s-0031-1280411
Natural Product Chemistry
Letters
© Georg Thieme Verlag KG Stuttgart · New York

New Triterpenoids from the Leaves of Cyclocarya paliurus

Shuai Li1 , Baosong Cui1 , Quan Liu1 , Li Tang2 , Yongchun Yang1 , Xiangju Jin1 , Zhufang Shen1
  • 1State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P. R. China
  • 2Division of Experimental Therapeutics, Department of Medicine, Columbia University, New York, New York, USA
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Publication History

received July 10, 2011 revised November 11, 2011

accepted November 14, 2011

Publication Date:
07 December 2011 (online)

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Abstract

Six new triterpenoids including four new secodammarane triterpenoid glycosides (1–4), an epoxydammarane triterpenoid glycoside (5), and a new secodammarane triterpenoid (6) were isolated from the ethanolic extract of the leaves of Cyclocarya paliurus. The structures of these compounds were elucidated by spectroscopic analysis methods. Compounds 1–6 were evaluated for their inhibitory activities against α-glucosidase, lipase, DPP-IV, and aldose reductase.

Key words

Cyclocarya paliurus - Juglandaceae - triterpenoid - secodammarane type - biological activity

Supporting Information

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Dr. Shuai Li

Institute of Materia Medica, Department of Natural Product Chemistry
Chinese Academy of Medical Sciences and Peking Union Medical College

1 Xian Nong Tan Street

Beijing 100050

P. R. China

Phone: +86 10 63 16 46 28

Fax: +86 10 63 01 77 57

Email: lishuai@imm.ac.cn