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Synthesis 2012(5): 653-676  
DOI: 10.1055/s-0031-1289686
REVIEW
© Georg Thieme Verlag Stuttgart ˙ New York

Decarboxylative Carbon-Carbon Bond-Forming Transformations of (Hetero)aromatic Carboxylic Acids

Josep Cornella, Igor Larrosa*
School of Biological and Chemical Sciences, Queen Mary University of London, Joseph Priestley Building, Mile End Road, E1 4NS, London, UK
Fax: +44(20)7882 7427; e-Mail: i.larrosa@qmul.ac.uk;
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Publication History

Received 2 November 2011
Publication Date:
03 February 2012 (online)

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Abstract

In the last decade, the use of (hetero)aromatic carboxylic acids as aryl donors in C-C bond-forming reactions has emerged as a powerful tool for organic synthesis. In this review article we describe the progress that has been achieved in the coupling of these acids with (pseudo)haloarenes, arenes, alkenes and alkynes, among other coupling partners, with particular emphasis on the most recent developments.

1 Introduction

2 Decarboxylative Cross-Couplings

3 Oxidative Decarboxylative Cross-Couplings

4 Miscellaneous Decarboxylative Transformations

5 Conclusions

Key words

carboxylic acids - decarboxylation - cross-coupling - palladium - catalysis

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1

Other types of carboxylic acids have also been used in carbon-carbon bond-forming reactions (e.g., propargylic, aliphatic or 2-oxo carboxylic acids - see ref. 2), however this review will focus on the use of(hetero)aromatic carboxylic acids.