2-Methoxypyridines functionalized in the 3-, 5-, or 6-position
and 2,6-dimethoxypyridines functionalized in the 3-position were
prepared from the corresponding bromo or iodo analogues by using
lithium dibutyl(isopropyl)magnesate(1-) and lithium chloride under
noncryogenic conditions. The procedure was optimized in terms of
the choice between two magnesates and the presence or absence of
lithium chloride in the reaction medium.
pyridines - magnesium - lithium - organometallic
reagents