Cycloartane Triterpenoids from Cassia occidentalis

Abstract

A phytochemical investigation of the whole plants of Cassia occidentalis led to the isolation of two new cycloartane triterpenoids, cycloccidentalic acids A and B (1 and 2), and five new related saponins, cycloccidentalisides I–V (3–7), together with sixteen known compounds. The structures of the isolated compounds were elucidated through detailed spectroscopic analyses, including 1D and 2D NMR techniques, and chemical methods. Compounds 2 and 5 showed modest anti-HIV-1 activities with EC₅₀ values of 2.23 µM and 4.36 µM, respectively, in comparison to the positive control.

Key words

Cassia occidentalis - Leguminosae - cycloartane triterpenoids - cycloccidentalic acids A and B - cycloccidentalisides I–V

References

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