Planta Med 2012; 78(15): 1626-1632
DOI: 10.1055/s-0032-1315198
Biological and Pharmacological Activity
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Blockade of the Renin-Angiotensin System with Delphinidin, Cyanin, and Quercetin

Warisara Parichatikanond
1   Department of Pharmacology, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand
,
Darawan Pinthong
2   Department of Pharmacology, Faculty of Science, Mahidol University, Bangkok, Thailand
,
Supachoke Mangmool
1   Department of Pharmacology, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand
› Author Affiliations
Further Information

Publication History

received 05 June 2012
revised 29 June 2012

accepted 12 July 2012

Publication Date:
07 August 2012 (online)

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Abstract

Overactivation of the renin-angiotensin system is one of the most important risk factors for the development of hypertension. The use of the crude extracts and/or active compounds, such as anthocyanins and quercetin, of herbal plants that have antihypertensive effects is beneficial for decreasing of blood pressure level. However, the molecular mechanisms by which anthocyanins (delphinidin and cyanin) and quercetin regulate the renin-angiotensin system are not completely understood. In this study, we demonstrate that delphinidin, cyanin, and quercetin interrupt the renin-angiotensin system signaling pathway by inhibiting the angiotensin-converting enzyme activity and decreasing its mRNA production. Furthermore, treatment with either delphinidin or cyanin significantly inhibited renin mRNA production. However, delphinidin, cyanin, and quercetin did not act as the angiotensin II type 1 receptor antagonist and did not play roles in the regulation of its internalization. The direct inhibition of components of the renin-angiotensin system advances our understanding of the antihypertensive effects of these compounds.

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