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Planta Med 2012; 78(17): 1857-1860
DOI: 10.1055/s-0032-1315386
Natural Product Chemistry
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Antiplasmodial and Antibacterial Activity of Compounds Isolated from Ormocarpum trichocarpum

Jude C. Chukwujekwu
1   Research Centre for Plant Growth and Development, School of Life Sciences, University of KwaZulu-Natal Pietermaritzburg, Scottsville, South Africa
,
Carmen A. de Kock
2   Department of Medicine, Division of Pharmacology, University of Cape Town, Cape Town, South Africa
,
Peter J. Smith
2   Department of Medicine, Division of Pharmacology, University of Cape Town, Cape Town, South Africa
,
Fanie R. van Heerden
3   School of Chemistry and Physics, University of KwaZulu-Natal Pietermaritzburg, Scottsville, South Africa
,
Johannes van Staden
1   Research Centre for Plant Growth and Development, School of Life Sciences, University of KwaZulu-Natal Pietermaritzburg, Scottsville, South Africa
› Institutsangaben
Weitere Informationen

Publikationsverlauf

received 25. Mai 2012
revised 04. September 2012

accepted 05. September 2012

Publikationsdatum:
11. Oktober 2012 (online)

Auch verfügbar auf
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Abstract

Using activity-guided fractionation based on in vitro antibacterial assays, five biflavonoids, among them two new ones, were isolated from the aerial parts of Ormocarpum trichocarpum. The isolated compounds showed MIC values in the range of 4.0 to 136.7 µM against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Klebsiella pneumonia and IC50 values in the range of 4.30 to 94.32 µM against the chloroquine-sensitive D10 Plasmodium falciparum strain.

Key words

Ormocarpum trichocarpum - Papilionaceae - antiplasmodial activity - antibacterial activity - biflavanone - biscoumarin

Supporting Information

 

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