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Synthesis 2013; 45(2): 251-259
DOI: 10.1055/s-0032-1317700
DOI: 10.1055/s-0032-1317700
paper
Studies toward the Total Synthesis of Carolacton
Authors
Further Information
Publication History
Received: 26 September 2012
Accepted after revision: 07 November 2012
Publication Date:
17 December 2012 (online)
Abstract
An efficient synthesis of the C1–C19 segment of carolacton is described, starting from d-ribose, (–)-β-citronellene and a homopropargylic alcohol, and which employs a Nozaki–Hiyama–Kishi (NHK) coupling as the key step. Other important steps are cross-metathesis and Evans aldol reactions.
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- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
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