Inhibitory Activity of Chemical Constituents from Arenaria serpyllifolia on Nitric Oxide Production

Abstract

Five new compounds, including one new xanthone, 1-hydroxy-5-methoxyxanthone 6-O-β-D-glucopyranoside (1), one new lignan, 3-(β-D-glucopyranosyloxymethyl)-2-(4-hydroxy-3-methoxyphenyl)-5-(3-acetoxypropyl)-7-methoxy-(2R,3S)-dihydrobenzofuran (2), and three new γ-pyrones, japonicumone A 4′-O-β-D-glucopyranoside (3), japonicumone B 3′-O-β-D-glucopyranoside (4), and japonicumone B 4′-O-β-D-glucopyranoside (5), together with eight known compounds (6–13) were isolated from the whole plants of Arenaria serpyllifolia. Their structures were elucidated on the basis of extensive spectroscopic analysis (UV, IR, HRESIMS, 1D- and 2D-NMR, and CD) as well as chemical methods. The isolated compounds were evaluated for their inhibitory effects on nitric oxide production in lipopolysaccharide-activated RAW 264.7 macrophages. Compounds 1–5, sacranoside A (9), and pedunculoside (13) showed potential nitric oxide inhibitory activities with IC₅₀ values ranging from 14.92 µM to 52.23 µM.

Key words

Arenaria serpyllifolia - Caryophyllaceae - γ-pyrone - nitric oxide production

• References

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