Synthesis 2015; 47(20): 3246-3256
DOI: 10.1055/s-0034-1378871
paper
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Polyfunctional Secondary Amines by the Reaction of Functionalized Organomagnesium Reagents with Tertiary Nitroalkanes

Vasudevan Dhayalan
Department of Chemistry, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377 Munich, Germany   Email: paul.knochel@cup.uni-muenchen.de
,
Paul Knochel*
Department of Chemistry, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377 Munich, Germany   Email: paul.knochel@cup.uni-muenchen.de
› Author Affiliations
Further Information

Publication History

Received: 10 June 2015

Accepted after revision: 01 July 2015

Publication Date:
17 August 2015 (online)


Abstract

Addition of polyfunctionalized aryl, heteroaryl, and tertiary alkylmagnesium reagents to tertiary nitroalkanes at 25 °C in tetrahydrofuran produces, after reductive workup with FeCl2 and NaBH4 in ethanol, the corresponding polyfunctional secondary amines in high yields.

Supporting Information

 
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