Palladium-Catalyzed Cross-Coupling between 7-Azaindoles and Reformatsky Reagents

Abstract

The preparation of various 2-(7-azaindolyl)carboxylic esters by Pd-catalyzed coupling of Reformatsky reagents with TBDMS-protected 3-bromo-7-azaindoles leading to a wide range of arylated ester derivatives is reported. After removal of the protecting group, the corresponding free 2-(7-azaindolyl)carboxylic esters are obtained in satisfactory yields.

Key words

azaindole - Reformatsky reagents - metalation - palladium - cross-coupling

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