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Synthesis 2015; 47(09): 1309-1316
DOI: 10.1055/s-0034-1380401
paper
© Georg Thieme Verlag Stuttgart · New York

Palladium-Catalyzed ortho-Acylation of 2-Aryl-1,2,3-triazoles with Toluene Derivatives

Ping He
a   Department of Chemistry, Tongji University, Siping Road 1239, Shanghai 200092, P. R. of China   Email: kuangcx@tongji.edu.cn
,
Qingshan Tian
a   Department of Chemistry, Tongji University, Siping Road 1239, Shanghai 200092, P. R. of China   Email: kuangcx@tongji.edu.cn
,
Chunxiang Kuang*
a   Department of Chemistry, Tongji University, Siping Road 1239, Shanghai 200092, P. R. of China   Email: kuangcx@tongji.edu.cn
b   Key Laboratory of Yangtze River Water Environment, Ministry of Education, Siping Road 1239, Shanghai 200092, P. R. of China
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Further Information

Publication History

Received: 01 December 2014

Accepted after revision: 23 January 2015

Publication Date:
27 February 2015 (online)

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Abstract

A palladium-catalyzed ortho-acylation of 2-aryl-1,2,3-triazoles was developed in which low-toxicity, stable, commercially available toluene derivatives were used as acyl sources. A wide variety of aryl ketones containing 1,2,3-triazoles were obtained in moderate to excellent yields. A plausible mechanism is proposed.

Key words

palladium - catalysis - acylations - triazoles - ketones

Supporting Information

    Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0034-1380401.
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