A New and Practical Synthesis of Vortioxetine Hydrobromide

Abstract

A new and improved synthetic route to vortioxetine hydrobromide is established on a hectogram scale through three simple steps in 63% yield and with 99% purity (HPLC). The key step is the cyclization of the piperazine ring in the final step. Purification methods for the intermediates involved in the route are given.

Key words

vortioxetine hydrobromide - new route - synthetic process - atypical antidepressant - green chemistry

• References

• 1 Y. M. and L. J. have contributed equally to this work.
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