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Synthesis 2015; 47(14): 2055-2062
DOI: 10.1055/s-0034-1380550
DOI: 10.1055/s-0034-1380550
paper
Synthesis of 4-(Dimethylamino)quinazoline via Direct Amination of Quinazolin-4(3H)-one Using N,N-Dimethylformamide as a Nitrogen Source at Room Temperature
Authors
Further Information
Publication History
Received: 17 January 2015
Accepted after revision: 18 March 2015
Publication Date:
22 April 2015 (online)
Abstract
An efficient direct amination of quinazolin-4(3H)-ones using N,N-dimethylformamide as a nitrogen source is described that affords the corresponding 4-(dimethylamino)quinazolines in high yields. This transformation proceeds through efficient 4-toluenesulfonyl chloride mediated C–OH bond activation at room temperature.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0034-1380550.
- Supporting Information (PDF)
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