Synthesis of 2-Arylpyrazolo[1,5-a]pyridines by Suzuki–Miyaura Cross-Coupling Reaction

Abstract

Convenient access to a variety of 2-arylated pyrazolo[1,5-a]pyridine via pyrazolo[1,5-a]pyridine-2-yl triflate using the Suzuki–Miyaura­ ­­cross-coupling reaction is described. Fifteen 2-arylpyrazolo[1,5-a]pyridine derivatives were synthesized in 52–95% yields.

Key words

Suzuki–Miyaura cross-coupling reaction - 2-arylpyrazolo[1,5-a]pyridine - triflate - regioselectivity - medicinal chemistry

• References

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