Triterpenoid Saponins from the Roots of Clematis argentilucida and Their Cytotoxic Activity

Abstract

The reinvestigation of the n-BuOH extract of the roots of Clematis argentilucida led to the isolation of four new oleanane-type triterpenoid saponins, 1–4, four known saponins, 5–8, first isolated from the species, together with ten saponins, 9−18, reported in the preceding papers. The structures of saponins 1–8 were elucidated by extensive spectroscopic analysis and chemical evidences. The cytotoxicity of all the saponins were evaluated against human tumor HL-60, HepG-2, and SGC-7901 cell lines. The monodesmosidic saponins 4, 7, 8, and 14–18 exhibited cytotoxic activity against the three cell lines with IC₅₀ values in the range of 0.87–19.48 µM.

Key words

Clematis argentilucida - Ranunculaceae - triterpenoid saponin - cytotoxicity

• References

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