Bioactive Depsidones from the Fungus Pilobolus heterosporus

Abstract

A new aromatic ester, pilobolusate (1), four new depsidones, pilobolusones A–D (2–5), five known depsidones, (6–10), and ergosterol were isolated from the fungus Pilobolus heterosporus. Their structures were established on the basis of spectroscopic data. Compounds 2 and 4–9 showed cytotoxicity against three cancer cell lines (KB, MCF-7, and NCI-H187) with IC₅₀ values in the range of 9.94–97.42 µM. In addition, compounds 2, 5, 9, and 10 exhibited antimalarial activity against Plasmodium falciparum with IC₅₀ values ranging from 3.67–23.56 µM.

Key words

Pilobolus heterosporus - Pilobolaceae - depsidone - cytotoxic - antimalarial

• References

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