Regioselective Suzuki–Miyaura Reactions of the Bis(triflate) of 6,7-Dihydroxy-2,2-dimethylchroman-4-one

Dávid Pajtás; Károly Dihen; Krisztina Kónya; Peter Langer

doi:10.1055/s-0035-1561265

Synlett, Table of Contents

Synlett 2016; 27(07): 1073-1076
DOI: 10.1055/s-0035-1561265

letter

Regioselective Suzuki–Miyaura Reactions of the Bis(triflate) of 6,7-Dihydroxy-2,2-dimethylchroman-4-one

Authors

Dávid Pajtás

^aDepartment of Organic Chemistry, University of Debrecen, 4032 Debrecen, Egyetem tér 1, Hungary

^bDepartment of Chemistry, University of Rostock, Albert-Einstein-Str. 3a, 18059 Rostock, Germany Email: peter.langer@uni-rostock.de
Károly Dihen

^aDepartment of Organic Chemistry, University of Debrecen, 4032 Debrecen, Egyetem tér 1, Hungary

^bDepartment of Chemistry, University of Rostock, Albert-Einstein-Str. 3a, 18059 Rostock, Germany Email: peter.langer@uni-rostock.de
Krisztina Kónya

^aDepartment of Organic Chemistry, University of Debrecen, 4032 Debrecen, Egyetem tér 1, Hungary

^bDepartment of Chemistry, University of Rostock, Albert-Einstein-Str. 3a, 18059 Rostock, Germany Email: peter.langer@uni-rostock.de
Peter Langer*

^bDepartment of Chemistry, University of Rostock, Albert-Einstein-Str. 3a, 18059 Rostock, Germany Email: peter.langer@uni-rostock.de

^cLeibniz-Institute for Catalysis e.V. at the University of Rostock (LIKAT), Albert-Einstein-Str. 3a, 18059 Rostock, Germany

Abstract

All articles of this category

Dedicated in memory to our dear colleague and friend Professor Tamás Patonay, PhD, DSc

Abstract

6,7-Diarylchromanone derivatives were prepared by Suzuki–Miyaura reactions of the bis(triflate) of 6,7-dihydroxy-2,2-dimethylchroman-4-one. Due to electronic factors the first attack proceeded with very good site selectivity at position 7.

Key words

Suzuki–Miyaura reaction - regioselectivity - palladium - catalysis - heterocycles

Full Text

References

References and Notes
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53 Procedure for Synthesizing 6,7-Diaryl-2,2-dimethylchroman-4-one Derivatives To a mixture of 2,2-dimethyl-6,7-ditriflyloxychroman-4-one (150 mg, 0.318 mmol), K₃PO₄ (202 mg, 0,95 mmol), and boronic acid (0.70 mmol) in dry 1,4-dioxane (4 mL) was added Pd(PPh₃)₄ (22 mg, 0.019 mmol) in a dried pressure tube under argon. The reaction mixture was stirred and heated in an aluminium heating block. The solvent was evaporated in vacuum, and the solid mixture was submitted to adsorptive filtration on silica gel using acetone as eluent removing the inorganic compounds. Silica was added to the solution, the acetone was evaporated, and the mixture was purified by column chromatography (eluent: heptane–EtOAc, the ratio is given below) giving the diarylated product. 6,7-Bis(4-methoxyphenyl)-2,2-dimethylchroman-4-oneStarting with 4 (150 mg, 0.32 mmol), K₃PO₄ (202 mg, 0.95 mmol), Pd(PPh₃)₄ (22 mg, 6 mol%), (4-methoxyphenyl)boronic acid (5b, 106 mg, 0.70 mmol), and 1,4-dioxane (4 mL), 6b was isolated as a white solid (84 mg 68%), mp 150–152.5 °C. ¹H NMR (300 MHz, 298 K, CDCl₃): δ = 7.61 (s, 1 H, 5-H), 7.05 (d, J= 10.5 Hz, 2 H, 2′,6′′-H) 6.98 (d, J= 10.5 Hz, 2 H, 2′,6′-H), 6.93 (s, 1 H, 8-H), 6.81 (m, 4 H, 3′,5′-H, 3′′,5′′-H), 3.72 (s, 3 H, 4′′-OCH₃), 3.71 (s, 3 H, 4′-OCH₃), 2.83 (s, 2 H, 3-H), 1.44 (s, 6 H, 2-CH₃). ¹³C NMR (75 MHz, 298 K, CDCl₃): δ = 191.7.7 (C-4), 158.6 (C-8a), 158.3 (C-4′′), 157.9 (C-4′), 147.5 (C-7), 132.5 (C-1′′), 132.3 (C-1′), 132.0 (C-6), 130.4 (C-2′,6′, C-2′′,6′′), 127.4 (C-5), 119.3 (C-8), 118.5 (C-4a), 113.6 (C-3′,5′, C-3′′5′′), 79.6 (C-2), 55.0 (OCH₃), 48.0 (C-3), 26.2 (CH₃). IR (ATR): υ = 2994, 2954, 2835, 1683, 1606, 1512, 1466, 1430, 1403, 1296, 1243, 1167, 1109, 1025, 951, 831, 655, 564, 549 cm^–1. GC–MS (EI, 70 eV): m/z = 388 [M^+∙, 100%], 373, 333, 261, 189. HRMS: m/z calcd for C₂₅H₂₄O₄: 388.16691; found: 388.16649.
54 Procedure for Synthesizing 7-Aryl-2,2-dimethyl-6-triflyloxy-chroman-4-one Derivatives To a mixture of 2,2-dimethyl-6,7-ditriflyloxychroman-4-one (150 mg, 0.318 mmol), K₃PO₄ (135 mg, 0,64 mmol), and boronic acid (0.349 mmol) in dry 1,4-dioxane (4 mL) was added Pd(PPh₃)₄ (11 mg, 0.0095 mmol) in a dried pressure tube under argon. The reaction mixture was stirred and heated in an aluminium heating block. The solvent was evaporated in vacuum, then the solid mixture was submitted to adsorptive filtration on silica gel using acetone as eluent removing the inorganic compounds. Silica was added to the solution, the acetone was evaporated, and the mixture was purified by column chromatography (eluent: heptane–EtOAc mixture, the ratio is given below) giving the monosubsituted product. 7-(4-Methoxyphenyl)-2,2-dimethyl-6-(triflyloxy)chroman-4-oneStarting with 4 (150 mg, 0.32 mmol), K₃PO₄ (135 mg, 0.64 mmol), Pd(PPh₃)₄ (11 mg, 3 mol%), (4-methoxyphenyl)boronic acid (5b, 53 mg, 0.35 mmol), and 1,4-dioxane (4 mL), 7b was isolated as a yellow oil (93 mg 68%), eluent: toluene–heptane (6:1). ¹H NMR (300 MHz, 298 K, DMSO-d ₆): δ = 7.71 (s, 1 H, 5-H), 7.47 (d, 2 H, J= 8.7 Hz, 2′,6′-H), 7.06 (d, 2 H, J= 8.7 Hz, 3′,5′-H), 3.82 (s, 3 H, OCH₃), 2.92(s, 2 H, 3-H), 1.44 (s, 6 H, CH₃). ¹³C NMR (75 MHz, 298 K, DMSO-d ₆): δ = 190.7 (C-4), 160.0 (C-4′), 158.6 (C-8a), 142.1 (C-6), 140.1 (C-7), 130.5 (C-2′,6′), 126.1 (C-1′), 120.9 (C-5), 118.9 (C-8), 118.8 (C-4a), 114.2 (C-3′,5′), 80.6 (C-2), 55.3 (OCH₃), 47.3 (C-3), 26.0 (CH₃). IR (ATR): υ = 2978, 2839, 1696, 1607, 1518, 1423, 1205, 1136, 1097, 1030, 915, 890, 832, 613, 564, 513 cm^–1. GC–MS (EI, 70 eV): m/z = 430 [M^+∙], 297, 255, 241 (100%), 215, 185, 157, 83. HRMS: m/z calcd for C₁₉H₁₇F₃O₆S: 430.06979; found: 430.06967.
55 Procedure for Synthesizing Differently Substituted 6,7-Diaryl-2,2-dimethylchroman-4-one DerivativesTo a mixture of 7-aryl-2,2-dimethyl-6-triflyloxychroman-4-one (0.120 mmol), K₃PO₄ (76 mg, 0,360 mmol), and boronic acid (0.264 mmol) in dry 1,4-dioxane (4 mL) was added Pd(PPh₃)₄ (8.3 mg, 0.0072 mmol) in a dried pressure tube under argon. The reaction mixture was stirred and heated in an aluminium heating block. The solvent was evaporated in vacuum, and then the solid mixture was submitted to adsorptive filtration on silica gel using acetone as eluent removing the inorganic compounds. Silica was added to the solution, the acetone was evaporated, and the mixture was purified by column chromatography (eluent: heptane–EtOAc mixture, the ratio is given below) giving the differently substituted product.6-(4-Hydroxyphenyl)-7-(4-methoxyphenyl)-2,2-dimethylchroman-4-oneStarting with 7b (50 mg, 0.12 mmol), K₃PO₄ (76 mg, 0.36 mmol), Pd(PPh₃)₄ (8.1 mg, 6 mol%), (4-hydroxyphenyl)boronic acid (5e, 35 mg, 0.264 mmol), and 1,4-dioxane (4 mL), 8g was isolated as a light yellow solid (36 mg 83%), mp 182.5–185°C, eluent: heptane–EtOAc (2:1). ¹H NMR(300 MHz, 298 K, CDCl₃): δ = 9.37 (s, 1 H, 5-H), 7.59 (s, 1 H, 8-H), 7.06 (d, J= 8.7 Hz, 2 H, 2′′,6′′-H), 6.86 (d, J= 8.7 Hz, 2 H, 2′,6′-H), 6.82 (d, J= 8.7 Hz, 2 H, 3′′,5′′-H), 6.62 (d, J= 8.7 Hz, 2 H, 3′,5′-H), 6.55 (s, 1 H, OH), 3.73 (s, 3 H, OCH₃), 2.82 (s, 2 H, 3-H), 1.44 (s, 6 H, CH₃). ¹³C NMR (75 MHz, 298 K, CDCl₃): δ = 191.7 (C-4), 158.6 (C-8a), 158.1 (C-4′′), 156.1 (C-4′), 147.5 (C-7), 132.9 (C-1′′), 132.1 (C-1′), 130.6 (C-6), 130.4 (C-2′,6′, C-2′′,6′′), 127.2 (C-5), 119.2 (C-8), 118.4 (C-4a), 115.0 (C-3′,5′), 113.5 (C-3′′,5′′), 79.6 (C-2), 55.0 (OCH₃), 48.0 (C-3), 26.2 (CH₃). IR (ATR): υ = 3299, 2921, 2847, 1737, 1668, 1602, 1512, 1406, 1243, 1163, 1109, 1026, 950, 834, 654, 560 cm^–1. GC–MS (EI, 70 eV): m/z = 374 [M^+∙, 100%], 359, 319, 290, 247, 219, 202, 179, 152. HRMS: m/z calcd for C₂₄H₂₂O₄: 374.15126; found: 374.15110.