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Synthesis 2016; 48(12): 1934-1938
DOI: 10.1055/s-0035-1561437
DOI: 10.1055/s-0035-1561437
special topic
Triflic Anhydride Mediated Ring-Opening/Recyclization Reaction of α-Carbamoyl α-Oximyl Cyclopropanes with DMF: Synthetic Route to 5-Aminoisoxazoles
Autoren
Weitere Informationen
Publikationsverlauf
Received: 08. März 2016
Accepted after revision: 31. März 2016
Publikationsdatum:
10. Mai 2016 (online)
Abstract
A facile and efficient synthesis of fully substituted 5-aminoisoxazoles was developed from α-cyclopropyl β-oximyl amides in the presence of triflic anhydride (Tf2O) in DMF under very mild conditions. The process involves sequential ring-opening and intramolecular cyclization reactions.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035-1561437.
- Supporting Information (PDF) (opens in new window)
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