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Synthesis 2017; 49(03): 677-684
DOI: 10.1055/s-0036-1588127
DOI: 10.1055/s-0036-1588127
paper
Four-Component Reaction between Secondary Phosphines, Primary Amines, Aldehydes, and Chalcogens: A Facile Access to Functionalized α-Aminophosphine Chalcogenides
Further Information
Publication History
Received: 26 July 2016
Accepted after revision: 04 December 2016
Publication Date:
19 December 2016 (online)
Abstract
The original four-component reaction between secondary phosphines, primary amines, aldehydes, and elemental sulfur or selenium occurs chemoselectively under mild conditions (60 °C, benzene, 3–9 h) to afford the hitherto unknown functionalized α-aminophosphine sulfides and selenides in good to excellent yields.
Key words
chemoselectivity - C–P and C–N bond formation - one-pot synthesis - aldehydes - amines - chalcogens - phosphinesSupporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0036-1588127. Included are the procedure for synthesis of 1c, crystallography data for 4d, and copies of 1H, 13C and 31P NMR spectra for all synthesized compounds.
- Supporting Information
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