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Synthesis 2017; 49(01): 151-158
DOI: 10.1055/s-0036-1588305
paper
© Georg Thieme Verlag Stuttgart · New York

Chiral Gold Complex Catalyzed Tandem Dehydrative Cyclization/Hetero-Diels–Alder Reaction

Yu-Liu Du
Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, 96 Jinzhai Road, Hefei 230026, P. R. of China   Email: gonglz@ustc.edu.cn
,
Feng Zhao
Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, 96 Jinzhai Road, Hefei 230026, P. R. of China   Email: gonglz@ustc.edu.cn
,
Zhi-Yong Han
Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, 96 Jinzhai Road, Hefei 230026, P. R. of China   Email: gonglz@ustc.edu.cn
,
Liu-Zhu Gong*
Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, 96 Jinzhai Road, Hefei 230026, P. R. of China   Email: gonglz@ustc.edu.cn
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Further Information

Publication History

Received: 30 June 2016

Accepted after revision: 07 August 2016

Publication Date:
09 September 2016 (online)

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Abstract

A tandem dehydrative cyclization/aza-hetero-Diels–Alder reaction catalyzed by gold(I) complex bearing BINOL-derived chiral phosphoramidite ligand has been developed. With this method, optically active chiral bicyclic tetrahydropyridazine derivatives could be obtained in one step from readily available starting materials.

Key words

asymmetric gold catalysis - tandem reaction - hetero-Diels–Alder reaction

Supporting Information

    Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0036-1588305.
  • Supporting Information
 

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