Preparation of Nonradioactive Standards and a Precursor for a Hypoxia ¹⁸F PET Tracer Derived from 1-(β-d-Galactopyranosyl)-2-nitroimidazole

^† Deceased.

Abstract

Acetyl-protected 1-(β-d-galactopyranosyl)-2-nitroimidazole was converted to a potential precursor for a fluorine-18 labeled hypoxia tumor marker. Two nonradioactive standards, the 6′-deoxy-6′-fluorogalactosyl and the 4′-deoxy-4′-fluoroglucosyl analogue were also prepared. These 2-nitroimidazole nucleosides were prepared by a modified Vorbrüggen coupling.

Key words

2-nitroimidazole - nucleosides - [¹⁸F]fluoride - d-glucose - d-galactose - tumor hypoxia - precursor

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