Green Organocatalytic Synthesis of Dihydrobenzofurans by Oxidation–Cyclization of Allylphenols

Published as part of the Special Topic Modern Cyclization Strategies in Synthesis

Abstract

A green and cheap protocol for the synthesis of dihydrobenzofurans via an organocatalytic oxidation of o-allylphenols is presented. The use of 2,2,2-trifluoroacetophenone and H₂O₂ as the oxidation system, leads to a highly useful synthetic method, where a variety of substituted o-allylphenols were cyclized in high yields.

Key words

organocatalysis - oxidation - cyclization - dihydrobenzofurans - hydrogen peroxide - green chemistry

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