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Synlett 2018; 29(14): 1847-1850
DOI: 10.1055/s-0037-1609573
DOI: 10.1055/s-0037-1609573
letter
Transition-Metal-Free Efficient Synthesis of Bisindole Sulfanes Using 2-(Fluorosulfonyl)difluoroacetic Acid
We are grateful for the financial support by the National Natural Science Foundation of China (21503610, 21502109), The Natural Science Foundation of Shaanxi Province (No. 2017JQ2017), Key Research & Development Project of Shaanxi Province (2017ZDXM-GY-040), and the Doctoral Scientific Research Foundation of Xi’an Polytechnic University (107020336).Further Information
Publication History
Received: 21 March 2018
Accepted after revision: 13 June 2018
Publication Date:
20 July 2018 (online)
Abstract
By using 2-(fluorosulfonyl)difluoroacetic acid as sulfur reagent, bisindole sulfanes were highly efficient synthesized under transition-metal-free conditions. Results indicate that this proceeded not at the relatively acidic C-2 position but rather selectively at the nucleophilic C-3 position to give the desired compounds with excellent regioselectivities and good yields.
Key words
synthesis - indoles - 2-(fluorosulfonyl)difluoroacetic acid - sulfur reagent - bisindole sulfanesSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1609573.
- Supporting Information
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