Synthesis 2020; 52(02): 239-245
DOI: 10.1055/s-0039-1690220
paper
© Georg Thieme Verlag Stuttgart · New York

Silver-Promoted Regioselective Oxidative Decarboxylative C–H Alkylation of Phenanthridines with Carboxylic Acids

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We thank the National Natural Science Foundation of China (No. 21672136, 21871174, 21772215) and Innovation Program of Shanghai Municipal Education Commission (No. 2019-01-07-00-09-E00008) for financial support.
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Publication History

Received: 12 September 2019

Accepted after revision: 02 October 2019

Publication Date:
29 October 2019 (online)


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§ These authors contributed equally to this manuscript

Abstract

A novel oxidative decarboxylative C–H alkylation of phenanthridines with carboxylic acids was developed for the efficient synthesis of multi-substituted phenanthridine derivatives. The given method features easy availability of starting materials, high regioselectivity, and mild conditions. Furthermore, a one-pot synthesis of multi-substituted phenanthridine derivatives was realized by the reaction of biphenyl isocyanides and carboxylic acid.

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