Herein, a concise and efficient protocol to synthesize a series of 2,6-disubstituted
4-fluoropyrimidines as universal and useful building blocks in medicinal chemistry
is reported. From readily accessible α-CF3 aryl ketones and different amidine hydrochlorides, this method provides a very practical
approach to this kind of compounds under mild conditions with good to excellent yields.
Key words
fluoropyrimidine - α-CF
3 aryl ketone - metal-free - mild conditions