Abstract
5-Bromo- and 5,5-dibromo-1,1,1-trihalo-4-methoxypent-3-en-2-ones (brominated enones)
have proven to be attractive building blocks for the construction of heterocyclic
and polyheterocyclic compounds bearing a trihalomethyl moiety through interesting
cyclocondensation, alkylation, and cycloaddition reactions. This review compiles all
of the reactions conducted with these brominated enones since they were first disclosed
in 2001.
1 Introduction
2 Synthesis and Initial Applications
3 Synthesis Using First-Generation Intermediates
4 Synthesis Using Second-Generation Intermediates
5 Synthesis Using Third-Generation Intermediates
6 Conclusions
Key words brominated enones - β-alkoxyvinyl ketones - bromo enones - trifluoromethyl - trichloromethyl
- heterocycles - aza-cycles
