Catalyst-Free Synthesis of 1,4-Dihydroquinolines and Pyrrolo[1,2-a]quinolines via Intermolecular [4+2]/[3+2] Radical Cyclization of N-Methylanilines with Alkynoates

Abstract

Intermolecular [4+2]/[3+2] radical annulation of N-methyl­anilines with alkynoates under metal- and photoredox-catalyst-free conditions provides a practical and efficient method to synthesize bioactive 1,4-dihydroquinolines and pyrrolo[1,2-a]quinolines in one pot in moderate to high overall yields.

Key words

catalyst-free - radical reaction - [4+2]/[3+2] cyclization - 1,4-dihydroquinolines - pyrrolo[1,2-a]quinolines

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