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Synlett 2021; 32(03): 299-303
DOI: 10.1055/s-0040-1706546
DOI: 10.1055/s-0040-1706546
letter
Palladium-Catalyzed C6-Selective C–H Acylation of 2-Pyridones
This work was supported by the National Natural Science Foundation of China (NSFC; 21676252 and 21506191).
Abstract
A versatile palladium-catalyzed C6-selective C–H acylation of 2-pyridones with commercially available aldehydes using TBHP as an oxidant has been developed. This protocol tolerated diverse functional groups and has excellent level of site selectivity. Moreover, it does not require silver salts as additives.
Key words
2-pyridones
C6-selective
palladium catalysis
C–H acylation
radical
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0040-1706546.
- Supporting Information
Publication History
Received: 22 June 2020
Accepted after revision: 25 September 2020
Article published online:
28 October 2020
© 2020. Thieme. All rights reserved
Georg Thieme Verlag KG
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