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Synthesis 2020; 52(18): 2698-2704
DOI: 10.1055/s-0040-1707148
DOI: 10.1055/s-0040-1707148
paper
Bio-inspired Functionalized Pyrrole-Pyridone Ensembles: Synthesis on the Platform of Acylethynylpyrroles
This work was supported by the Russian Science Foundation (Project 19-73-10063).Further Information
Publication History
Received: 06 April 2020
Accepted after revision: 18 May 2020
Publication Date:
16 June 2020 (online)
Abstract
An efficient synthesis of pharmacologically oriented, functionalized pyrrole-pyridone ensembles by the reaction of available acylethynylpyrroles with methylene active amides in almost quantitative yields has been implemented. The cyclocondensation proceeds smoothly at room temperature in a KOH/DMSO superbase suspension.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0040-1707148.
- Supporting Information
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