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Synthesis 2023; 55(04): 547-564
DOI: 10.1055/s-0042-1753053
DOI: 10.1055/s-0042-1753053
short review
Acceptorless Dehydrogenation of Aliphatics, Amines, and Alcohols with Homogeneous Catalytic Systems
21732006We grateful acknowledge support from the National Basic Research Program of China (2021YFA1500100, 2021YFA1501700), National Natural Science Foundation of China (21825109, 21821002, 21732006, 22072178, K21211026), Guangdong Provincial Key Laboratory of Catalysis (2020B121201002), Shenzhen Science and Technology Program (KQTD20180411143514543 and K20215006), K. C. Wong Education Foundation, Youth Interdisciplinary Team (JCTD-2021-11) (CAS), and Ningbo Municipal Bureau of Science and Technology (2019B10096).
Abstract
The dehydrogenation of saturated substrates is fundamentally essential for producing value-added unsaturated organic molecules both in academia and industry. In recent years, homogeneously catalyzed acceptorless C–C, C–N, and C–O bond desaturations have attracted increasing attention due to high atom economy, environmentally benign nature, and wide availability of the starting materials. This short review discusses the acceptorless dehydrogenation of aliphatics, alcohols, and amines by homogeneous catalytic systems based on two categories of reaction mechanisms: thermal transition-metal-catalyzed two-electron pathway and photoredox catalyzed or electrochemically driven one-electron pathway.
1 Introduction
2 Catalytic Acceptorless Dehydrogenation of Aliphatics
3 Catalytic Acceptorless Dehydrogenation of Amines
4 Catalytic Acceptorless Dehydrogenation of Alcohols
5 Conclusion
Key words
acceptorless dehydrogenation - homogeneous catalysis - thermal transition-metal catalysis - photoredox catalysis - electrochemistryPublication History
Received: 27 July 2022
Accepted after revision: 19 September 2022
Article published online:
03 November 2022
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For selected reviews, see:
For other examples of pincer-ligated transition-metal-catalyzed acceptorless dehydrogenation of alkanes, see:
For other selected examples of precious-metal-catalyzed CAD reactions from saturated N-heterocycles, see:
For selected reviews, see:
For other selected examples of precious-metal-catalyzed CAD reactions from alcohols, see:
For other examples of 3d-transition-metal-complex catalyzed acceptorless dehydrogenation of alcohols, see:
For selected examples of heterogeneous catalytic systems, see: