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Planta Med 2018; 84(03): 201-207
DOI: 10.1055/s-0043-119888
Natural Product Chemistry and Analytical Studies
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Grincamycins I – K, Cytotoxic Angucycline Glycosides Derived from Marine-Derived Actinomycete Streptomyces lusitanus SCSIO LR32

Zhenzhu Lai
1   School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China
2   CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, RNAM Center for Marine Microbiology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China
,
Jianchen Yu
3   Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
,
Huiping Ling
1   School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China
,
Yongxiang Song
2   CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, RNAM Center for Marine Microbiology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China
,
Jie Yuan
3   Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
,
Jianhua Ju
2   CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, RNAM Center for Marine Microbiology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China
,
Yiwen Tao
1   School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China
4   The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China
,
Hongbo Huang
2   CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, RNAM Center for Marine Microbiology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China
› Author Affiliations
Further Information

Publication History

received 02 July 2017
revised 04 September 2017

accepted 14 September 2017

Publication Date:
26 September 2017 (online)

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Abstract

Three new angucycline glycosides, designated grincamycin I (1), J (2), and K (3), together with the known congener A-7884 (4), were isolated from marine-derived actinomycete Streptomyces lusitanus SCSIO LR32. The structures of the new compounds were elucidated by comprehensive spectral data analysis. Compounds 2 and 4 exhibited antitumor activity against human cancer cells MDA-MB-435, MDA-MB-231, NCI-H460, HCT-116 and HepG2, and human normal breast epithelial cell MCF10A with IC50 values ranging from 0.4 to 6.9 µM. In addition, A-7884 (4) demonstrated antimicrobial activity against Micrococcus luteus with an MIC value of 1.95 µg/mL.

Key words

angucycline glycoside - naphthacenequinone - cytotoxicity - marine actinomycete - Streptomyces lusitanus - Streptomycetaceae

Supporting Information

    HR-ESI-MS and NMR spectra of grincamycins I (1), J (2), and K (3) are available as Supporting Information.

  • Supporting Information
 

  • References

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