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Planta Med 2002; 68(1): 16-19
DOI: 10.1055/s-2002-20050
Original Paper
Pharmacology
© Georg Thieme Verlag Stuttgart · New York

Antioxidant Effects of 1,5-Anhydro-D-fructose, a New Natural Sugar, in vitro

Kazuyo  Yamaji1 , Krishna Pada Sarker1 , Ikuro  Maruyama1 , Susumu  Hizukuri2
  • 1Department of Laboratory and Molecular Medicine, Faculty of Medicine, Kagoshima University, Kagoshima City, Japan
  • 2Kagoshima University, Kagoshima City, Japan
Further Information

Publication History

December 28, 2000

May 24, 2001

Publication Date:
31 January 2002 (online)

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Abstract

The antioxidant effects of 1,5-anhydro-D-fructose (1,5-AF), a unique anhydrohexulose, were studied in 1,1-diphenyl-2-picrylhydrazyl (DPPH) solution, in human cells along with lipid peroxidation of low-density lipoprotein (LDL). We have confirmed that 1,5-AF scavenges DPPH radicals directly in solution and inhibits the formation of hydrogen peroxide and superoxide anion, typical reactive oxygen species (ROS), induced by phorbol myristate acetate (PMA) in a dose-dependent manner in THP-1 cells. We also observed the dose-dependent antioxidant effects of 1,5-AF on copper-mediated LDL oxidation. These findings suggest that 1,5-AF might play a role in reducing the risk of atherosclerosis and may help prevent coronary heart disease.

Key words

1,5-Anhydro-D-fructose - reactive oxygen species - low-density lipoprotein peroxidation - antioxidant

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Kazuyo Yamaji

Department of Laboratory and Molecular Medicine

Faculty of Medicine

Kagoshima University, 8-35-1

Sakuragaoka

Kagoshima City, 890-8520

Japan

Phone: +81-99-275-5437

Fax: +81-99-275-2629

Email: yamaji@m3.kufm.kagoshima-u.ac.jp