The First Generation of Azulenyl-Lithium and -Magnesium: A Novel, Versatile Method of Introducing a Substituent at the 2-Position of an Azulene Skeleton

Abstract

1,3-Dihaloazulenes were effectively transformed into 2-substituted azulenes through lithiation at the 2-position by proton abstraction. Furthermore, 1,3-dichloro-2-iodoazulene was found to undergo iodine-lithium and -magnesium exchange to generate the corresponding azulenyl-lithium and -magnesium, respectively.

azulenes - lithium - magnesium - metalations - halogens

References and Notes

For some syntheses of oligomers, see:

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