Regioselective Synthesis of Dihydrofuro[3,2-g]coumarin-6-one

Abstract

New regioselective routes for the preparation of dihydrofuro[3,2-g]coumarin-6-one (5) have been studied. An efficient three-step synthesis of methyl 3-(5′-chloroacetyl-2′,4′-dihydroxy­phenyl)propanoate (7) from resorcinol was the key for the success of our preparation of the target compound 5.

Key words

acylations - dehydrogenations - rearrangements - regio­selectivity - ring closure

References

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  Our approach to 7 is reminiscent of that used in this reference but the method described by us provide a more efficient 3-step synthetic route from resorcinol.